The Possible Consequences of Combining Lorazepam and Buprenorphine/Naloxone: A Case Review

September 5, 2011

Administering a benzodiazepine depressant to patients taking buprenorphine/naloxone can be life-threatening. Unfortunately, many ED health care providers are unaware of this potentially lethal combination. The following case study illustrates how these medications, when administered together, can adversely affect patient outcome. (Source: Journal of Emergency Nursing: JEN)

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The pharmacodynamic and pharmacokinetic profile of intranasal crushed buprenorphine and buprenorphine/naloxone tablets in opioid abusers

September 5, 2011

Conclusions.  It is difficult to determine if observed differences in abuse potential between intranasal buprenorphine and buprenorphine/naloxone are clinically relevant at the doses tested. Greater bioavailability and faster onset of pharmacodynamic effects compared to sublingual administration suggests a motivation for intranasal misuse in nonâ€�dependent opioid abusers. However, significant naloxone absorption from intranasal buprenorphine/naloxone administration may […]

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Collaborative Care of Opioid-Addicted Patients in Primary Care Using Buprenorphine: Five-Year Experience [Original Investigation]

September 5, 2011

Conclusion  Collaborative care with nurse care managers in an urban primary care practice is an alternative and successful treatment method for most patients with opioid addiction that makes effective use of time for physicians who prescribe buprenorphine. (Source: Archives of Internal Medicine)

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Tipranavir/Ritonavir Induction of Buprenorphine Glucuronide Metabolism in HIV-Negative Subjects Chronically Receiving Buprenorphine/Naloxone.

September 5, 2011

Conclusions and Scientific Significance: This study further elucidates the effects of TPV/r on glucuronidation. The current evaluation of glucuronide metabolites of BUP and norBUP are suggestive of combined inhibition of Uridine diphosphate (UDP)-glucuronosyltransferase of the 1A family and cytochrome P450 3A4 that spares UGT2B7 leading to a shunting of BUP away from production of norBUP […]

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An Adverse Reaction to Buprenorphine/Naloxone Induction in Prison: A Case Report

September 5, 2011

Buprenorphine is an effective treatment for opiate dependence. Prisoners with histories of opiate dependence who are inducted on buprenorphine prior to release are at decreased risk of post-release relapse and overdose, yet many clinicians are unaware of the risks related to buprenorphine induction for non-opiate tolerant patients, especially those on other psychotropic medications. The authors […]

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The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Substance Use and Related Disorders. Part 2: Opioid dependence.

September 5, 2011

Conclusions. There is enough high quality data to formulate evidence-based guidelines for the treatment of opioid abuse and dependence. This task force report provides evidence for the efficacy of a number of medications to treat opioid abuse and dependence, particularly the opioid agonists methadone or buprenorphine. These medications have great relevance for clinical practice. PMID: […]

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Buprenorphine/naloxone: Various toxicities following unintentional exposure in infants and children: 9 case reports

September 5, 2011

(Source: Reactions)

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Buprenorphine/naloxone: Urinary retention (first report) and rash: case report

September 5, 2011

(Source: Reactions)

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Table of Contents

September 5, 2011

AbstractColumn Promoting Suboxone Film, Criticizing Methadone, Angers FieldCenter Takes Proactive Approach on Integrated Care, Research EffortsStates Encouraging Providers to Enroll in MedicaidLegal Action to Enforce Parity Contemplated, Ramstad Tells ADAWJournalist in Recovery Describes Her Experience in MATBriefly NotedIn the StatesBusinessResourcesComing up (Source: Alcoholism and Drug Abuse Weekly) MedWorm Sponsor Message: Find out how you can […]

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NY Times on Suboxone Abuse in Prison

September 5, 2011

The NY Times this morning had an interesting article on a problem of which I was completely unaware: the abuse of Suboxone in prisons. According to the report: “Innovative smugglers have turned crushed Suboxone pills into a paste and spread it under stamps or over children’s artwork, including pages from a princess coloring book found […]

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