The Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Patients with Chronic, Non-Malignant Pain who are Maintained on Sublingual Buprenorphine/Naloxone

September 5, 2011

The Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Patients with Chronic, Non-Malignant Pain who are Maintained on Sublingual Buprenorphine/Naloxone Neuropsychopharmacology advance online publication, October 27, 2010. doi:10.1038/npp.2010.172 Authors: Jermaine D Jones, Maria A Sullivan, Jeanne Manubay, Suzanne K Vosburg & Sandra D Comer Keywords: opioids; pain/analgesics; addiction & substance abuse; psychopharmacology; buprenorphine (Source: Neuropsychopharmacology)

Read the full article →

Accidental and Non-Accidental Ingestion of Methadone and Buprenorphine in Childhood: A Single Center Experience, 1999-2009.

September 5, 2011

Conclusions: Accidental and non-accidental ingestion of methadone and buprenorphine by children is increasing in proportion to increased clinical use and availability. Health providers should be aware of this increased risk and be able to provide appropriate treatment and family support. PMID: 21047302 [PubMed – as supplied by publisher] (Source: Current Drug Safety)

Read the full article →

N.Y. to Prescribe Suboxone for Ex-Prisoners

September 5, 2011

The state of New York plans to give some state prisoners the opiate-treatment drug Suboxone to help them stay off heroin upon release. (Source: Alcohol, Tobacco and Other Drugs News)

Read the full article →

The prevalence and correlates of buprenorphine inhalation amongst opioid substitution treatment (OST) clients in Australia

September 5, 2011

Conclusions: Our data indicates that the inhalation of buprenorphine has occurred in a significant minority of Australian OST clients. The motivations, contexts and potential health consequences of buprenorphine use by these atypical routes of administration, particularly in a correctional setting, warrant further exploration. (Source: International Journal of Drug Policy) MedWorm Sponsor Message: Find out how […]

Read the full article →

Sublingual Buprenorphine

September 5, 2011

OPIOID-DEPENDENT PATIENTS present a unique perioperative care challenge. These patients are managed as outpatients in several different manners. The type of treatment that such patients receive can have a profound impact on their perioperative care when they present for surgery. One management option is the use of sublingual (SL) buprenorphine to treat opioid dependence. This […]

Read the full article →

Orexo Reports Phase I Trial Results For OX219, A Novel Sublingual Tablet Formulation For The Treatment Of Opioid Dependence

September 5, 2011

Orexo AB (STO:ORX) announces successful completion of the initial pharmacokinetic trial in the OX219 project. In the comparative bioavailability study, the OX219 buprenorphine/naloxone sublingual tablet formulation demonstrated favourable profiles compared to the comparator Suboxone®, which is the market leading product for treatment of opioid dependence. Global value of the opioid dependence market today is approximately […]

Read the full article →

Prescribers’ perceptions of the diversion and injection of medication by opioid substitution treatment patients

September 5, 2011

Conclusions.Australian prescribers perceive most patients adhere with OST, although they may underestimate the levels of diversion. Prescribers’ beliefs about patients’ behaviours are important and influence decisions to prescribe, medication choice and suitability for unsupervised dosing. The uncertainties in assessing and responding to diversion/injection may be a factor deterring prescribers’ participation in OST.[Larance B, Degenhardt L, […]

Read the full article →

Hospital Pharmacists Scrambling Amid Vast Drug Shortages: Emergency Physicians Between Roc and a Hard Place

September 5, 2011

On the Web site of the American Society of Health System Pharmacists (ASHP), the list goes on for pages: atracurium, bumetanide, buprenorphine, clindamycin, cisatracurium, epinephrine, fentanyl, furosemide, lipid emulsion, lidocaine, metronidazole, naloxone, propofol, rocuronium, succinylcholine, sulfamethoxazole-trimethoprim, torsemide, vancomycin hydrochloride, vecuronium. They are all sterile injectable drugs that an emergency physician might use every day, and […]

Read the full article →

Induction of Opioid-Dependent Individuals Onto Buprenorphine and Buprenorphine/Naloxone Soluble-Films.

September 5, 2011

This study compared the ability of buprenorphine (B) and B/N films to suppress spontaneous withdrawal in opioid-dependent volunteers. Participants were maintained on morphine and underwent challenge sessions to confirm sensitivity to naloxone-induced opioid withdrawal. Subjects were randomized to receive either B (16 mg, n = 18) or B/N (16/4 mg, n = 16) soluble films for 5 […]

Read the full article →

Calling bull%&@$ on addiction treatment bullies

September 5, 2011

About three years ago, I was attending a national conference on public health (American Public Health Association) and presenting my posters on the relationship between drug use and violence, and sexually transmitted infections and injecting drugs. As I walked the aisles I ran into a woman who runs a Florida addiction “treatment” facility. We talked […]

Read the full article →