Conclusions: In Chinese and Thai opioid-dependent injectors, we found BUP/NX to be effective in reducing opioid withdrawal symptoms and safe during short-term use. ALT increases were observed over 4-week-follow-up, which are consistent with reports from Western populations. Long-term safety and efficacy evaluations are indicated. (Source: International Journal of Drug Policy)

Source: Canadian Agency for Drugs and Technologies in Health (CADTH) Area: News This Rapid Response Report from the Canadian Agency for Drugs and Technologies in Health (CADTH) discusses the available evidence regarding the comparative clinical efficacy and safety of short term (<4 weeks) use of Suboxone® (buprenorphine/naloxone) compared with other opioid detoxification agents such as […]

Conclusion: These findings suggest that variations in the amount of compensation for completing assessments can differentially affect outcome measurements, depending on treatment group assignment. Scientific Significance: Adequate financial compensation may minimize bias when treatment condition is associated with differential dropout and may be a cost-effective way to reduce attrition. Moreover, active users may be more […]

We describe a mechanism whereby chronic blockade of opiate receptors, in spite of only partial opiate agonist action, may ultimately block dopaminergic activity causing anti-reward and relapse potential. While the direct comparison is not as yet available, toxicity to buprenorphine can be found in the scientific literature. In considering our cautionary note in this commentary, […]