On the Web site of the American Society of Health System Pharmacists (ASHP), the list goes on for pages: atracurium, bumetanide, buprenorphine, clindamycin, cisatracurium, epinephrine, fentanyl, furosemide, lipid emulsion, lidocaine, metronidazole, naloxone, propofol, rocuronium, succinylcholine, sulfamethoxazole-trimethoprim, torsemide, vancomycin hydrochloride, vecuronium. They are all sterile injectable drugs that an emergency physician might use every day, and […]

About three years ago, I was attending a national conference on public health (American Public Health Association) and presenting my posters on the relationship between drug use and violence, and sexually transmitted infections and injecting drugs. As I walked the aisles I ran into a woman who runs a Florida addiction “treatment” facility. We talked […]

Conclusions.  It is difficult to determine if observed differences in abuse potential between intranasal buprenorphine and buprenorphine/naloxone are clinically relevant at the doses tested. Greater bioavailability and faster onset of pharmacodynamic effects compared to sublingual administration suggests a motivation for intranasal misuse in non‐dependent opioid abusers. However, significant naloxone absorption from intranasal buprenorphine/naloxone administration may […]

Conclusions and Scientific Significance: This study further elucidates the effects of TPV/r on glucuronidation. The current evaluation of glucuronide metabolites of BUP and norBUP are suggestive of combined inhibition of Uridine diphosphate (UDP)-glucuronosyltransferase of the 1A family and cytochrome P450 3A4 that spares UGT2B7 leading to a shunting of BUP away from production of norBUP […]