Respiratory effects of buprenorphine/naloxone alone and in combination with diazepam in naive and tolerant rats.

In conclusion, differences in respiratory effects between BUP/NLX and BUP are only significant in combination with DZP, with increased depression in naive rats but reduced depression in in BUP-tolerant rats. However, BUP/NLX benefits in humans remain to be determined.
PMID: 24769261 [PubMed – as supplied by publisher] (Source: Toxicology Letters)