October 9, 2011
Abstract: Background: This series of studies examines the pharmacokinetic/pharmacodynamic interactions between buprenorphine, an opioid partial agonist increasingly used in treatment of opioid dependence, and rifampin, a medication used as a first line treatment for tuberculosis; or rifabutin, an alternative antituberculosis medication.Methods: Opioid-dependent individuals on stable doses of buprenorphine/naloxone underwent two, 24-h blood sampling studies: (1) […]
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October 9, 2011
Conclusions: Gender-related differences exist in the pharmacokinetics of buprenorphine; differences in body composition appear to have a major impact; differences in CYPA-dependent metabolism may also contribute. (Source: Drug and Alcohol Dependence) MedWorm Sponsor Message: Please support the DoctorsInChains.org campaign for the health workers in Bahrain. #FreeDoctors
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