Zubsolv comparable to Suboxone in retention, cravings: Study

March 2, 2016

(Source: Alcoholism and Drug Abuse Weekly)

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Chronic pain volatility predicts outcomes of buprenorphine-naloxone for prescription opioid dependence

March 2, 2016

Aims: Prescription opioid (PO) dependence frequently co-occurs with chronic pain. Prior studies did not find poorer buprenorphine-naloxone (BUP-NLX) outcomes in chronic pain patients, but more dynamic indicators of chronic pain may impact treatment. We hypothesized that greater pain volatility would predict opioid use during BUP-NLX taper in adults with PO dependence and chronic pain. (Source: […]

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Does early response to buprenorphine-naloxone predict treatment outcome in prescription opioid dependence?

March 2, 2016

Aims: The 10-site Prescription Opioid Addiction Treatment Study, conducted in the NIDA Clinical Trials Network, examined different lengths of buprenorphine-naloxone (bup-nx) plus medical management, with or without additional counseling, for patients dependent upon prescription opioids. Among patients (N=360) receiving 12 weeks of bup-nx stabilization, 49% achieved successful opioid use outcomes at week 12. The aim […]

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Buprenorphine/naloxone pediatric ingestion: Exposure rates differ between film and tablet formulations

March 2, 2016

Aims: Buprenorphine ingestion can cause life-threatening poisoning in young children. Previous reports have found that film formulations are associated with lower pediatric exposure rates than tablet formulations. The purpose of this study is to determine whether these relationships are stable over time. (Source: Drug and Alcohol Dependence) MedWorm Sponsor Message: Directory of the best January […]

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Differences between heroin and non-prescription opioid analgesics users in treatment-seeking opioid-dependent young adults

March 2, 2016

Aims: The purpose of this study was to evaluate the demographic, infectious disease status and clinical severity of dependence among heroin users compared to non-prescribed opioid analgesic users in a group of opioid dependent young adults seeking treatment with buprenorphine/naloxone. (Source: Drug and Alcohol Dependence)

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Feasibility of very low dose naltrexone and buprenorphine transition from opioid use to extended-release naltrexone

March 2, 2016

Aims: The approval of extended release injectable naltrexone suspension (XR-NTX) has introduced a new option for treating opioid addiction, but the absence of physiological opioid dependence is a necessary and challenging first step for starting therapy. Outpatient detoxification gives poor results and inpatient detoxification is either unavailable or too brief for the physiological effects of […]

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Primary care buprenorphine detoxification vs. maintenance for prescription opioid dependence

March 2, 2016

Aims: The favorable clinical characteristics and improved treatment outcomes for prescription opioid dependent (POD) patients, and modest severity of withdrawal symptoms with buprenorphine/naloxone (bup/nx), have led physicians to offer detoxification with bup/nx for POD patients. We sought to determine whether bup/nx stabilization followed by detoxification (DTX) or maintenance (MTN) leads to greater reduction in illicit […]

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Buprenorphine/naloxone abuse and diversion: Film rates are less than tablet rates

March 2, 2016

This study extends the comparison of diversion and abuse rates between buprenorphine sublingual formulations. (Source: Drug and Alcohol Dependence)

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Cognitive behavioral therapy improves treatment outcome for prescription opioid users in primary care based buprenorphine/naloxone treatment

March 2, 2016

Aims: To assess whether response to Cognitive Behavioral Therapy (CBT) differed between primarily prescription opioid users (POU) and primarily heroin users (HU) receiving primary care buprenorphine/naloxone (BUP) treatment with physician management (PM). (Source: Drug and Alcohol Dependence) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

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Medicaid budget impact of generic buprenorphine/naloxone tablet

March 2, 2016

Aims: The buprenorphine/naloxone (Bup/Nal)combination for the treatment of opioid dependence is available in two forms – sublingual film and tablet. Recent studies demonstrated that treatment with film leads to improved treatment retention and lower healthcare costs. In March 2013 generic tablets appeared on the market. A budget impact model was built to compare health care […]

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