Tipranavir/Ritonavir Induction of Buprenorphine Glucuronide Metabolism in HIV-Negative Subjects Chronically Receiving Buprenorphine/Naloxone.

March 2, 2016

Conclusions and Scientific Significance: This study further elucidates the effects of TPV/r on glucuronidation. The current evaluation of glucuronide metabolites of BUP and norBUP are suggestive of combined inhibition of Uridine diphosphate (UDP)-glucuronosyltransferase of the 1A family and cytochrome P450 3A4 that spares UGT2B7 leading to a shunting of BUP away from production of norBUP […]

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An Adverse Reaction to Buprenorphine/Naloxone Induction in Prison: A Case Report

March 2, 2016

Buprenorphine is an effective treatment for opiate dependence. Prisoners with histories of opiate dependence who are inducted on buprenorphine prior to release are at decreased risk of post-release relapse and overdose, yet many clinicians are unaware of the risks related to buprenorphine induction for non-opiate tolerant patients, especially those on other psychotropic medications. The authors […]

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The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Substance Use and Related Disorders. Part 2: Opioid dependence.

March 2, 2016

Conclusions. There is enough high quality data to formulate evidence-based guidelines for the treatment of opioid abuse and dependence. This task force report provides evidence for the efficacy of a number of medications to treat opioid abuse and dependence, particularly the opioid agonists methadone or buprenorphine. These medications have great relevance for clinical practice. PMID: […]

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Buprenorphine/naloxone: Urinary retention (first report) and rash: case report

March 2, 2016

(Source: Reactions)

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Buprenorphine/naloxone: Various toxicities following unintentional exposure in infants and children: 9 case reports

March 2, 2016

(Source: Reactions)

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Table of Contents

March 2, 2016

AbstractColumn Promoting Suboxone Film, Criticizing Methadone, Angers FieldCenter Takes Proactive Approach on Integrated Care, Research EffortsStates Encouraging Providers to Enroll in MedicaidLegal Action to Enforce Parity Contemplated, Ramstad Tells ADAWJournalist in Recovery Describes Her Experience in MATBriefly NotedIn the StatesBusinessResourcesComing up (Source: Alcoholism and Drug Abuse Weekly)

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NY Times on Suboxone Abuse in Prison

March 2, 2016

The NY Times this morning had an interesting article on a problem of which I was completely unaware: the abuse of Suboxone in prisons. According to the report: “Innovative smugglers have turned crushed Suboxone pills into a paste and spread it under stamps or over children’s artwork, including pages from a princess coloring book found […]

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Table of Contents

March 2, 2016

AbstractNAATP: Goodbye to Last Year, Hello to Health Reform, New CEOTASC Stays Focused on Reform Despite Illinois Budget ChallengesChildhood ADHD Found to Predict SUDs 10 Years LaterFDA Says Okay to Give Vivitrol or Suboxone Without CounselingCalifornia Set to Eliminate ADP; Counties Would Administer FundsBriefly NotedResourcesComing up (Source: Alcoholism and Drug Abuse Weekly)

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Differential Pharmacological Actions of Methadone and Buprenorphine in Human Embryonic Kidney 293 Cells Coexpressing Human μ-Opioid and Opioid Receptor-Like 1 Receptors.

March 2, 2016

In this study, we compared their effects on adenylate cyclase (AC) activity in human embryonic kidney (HEK) 293 cells stably overexpressing human μ-opioid receptor (MOR) and nociceptin/opioid receptor-like 1 receptor (ORL1) simultaneously. After acute exposure, methadone inhibited AC activity; however, buprenorphine induced compromised AC inhibition. When naloxone was introduced after 30 min incubation with methadone, the […]

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Transfer from high dose methadone to buprenorphine/naloxone.

March 2, 2016

Authors: Wallace M PMID: 21853690 [PubMed – in process] (Source: Australian Nursing Journal)

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